Nonresponsiveness to standard treatment in cutaneous leishmaniasis: A case series from Sri Lanka
نویسندگان
چکیده
Leishmaniasis is caused by parasitic protozoa of the genus Leishmania. Cutaneous leishmaniasis (CL) is endemic in Sri Lanka with over 3000 cases during the last decade and numbers are increasing. Treatment options available in Sri Lanka for CL include intralesional/intramuscular sodium stibogluconate and cryotherapy. Eight cases of treatment failure with standard therapy are reported from the Dermatology Clinic, Teaching Hospital Anuradhapura. Therapeutic regimes aim for clinical healing, these patients responded poorly to anti-leishmanial therapy, indicating the need for close monitoring, explore alternative treatment options and to investigate for drug resistance in parasites.
منابع مشابه
Leishmania donovani and Cutaneous Leishmaniasis, Sri Lanka
To investigate the relationship of cutaneous leishmaniasis isolates from Sri Lanka to known species, we performed DNA sequencing and microsatellite analyses. We identified Leishmania donovani as the agent of Sri Lanka cutaneous leishmaniasis and showed that these parasites are closely related to those causing visceral leishmaniasis in the Indian subcontinent.
متن کاملCutaneous Leishmaniasis, Sri Lanka
Cutaneous leishmaniasis (CL) is an emerging disease in Sri Lanka. Of 116 patients with clinical symptoms suggestive of CL, 86 were confirmed positive for Leishmania donovani. Most patients had single dry lesions, usually on the face. Patients were from 5 of the 7 agroclimatic zones in Sri Lanka.
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Cutaneous leishmaniasis is now an endemic disease in Sri Lanka. Many studies have focussed on various aspects of this disease but the knowledge, particularly on epidemiological and vector aspects is still poor and the awareness among the general public and even medical/paramedical personnel regarding this disease remains grossly inadequate. The steady increase in the numbers and spread of cutan...
متن کاملGenetic diversity of Leishmania donovani that causes cutaneous leishmaniasis in Sri Lanka: a cross sectional study with regional comparisons
BACKGROUND Leishmania donovani is the etiological agent of visceral leishmaniasis (VL) in the Indian subcontinent. However, it is also known to cause cutaneous leishmaniasis (CL) in Sri Lanka. Sri Lankan L. donovani differs from other L. donovani strains, both at the molecular and biochemical level. To investigate the different species or strain-specific differences of L. donovani in Sri Lanka ...
متن کاملFirst successful in vitro culture of Leishmania sp. causing autochthonous visceral leishmaniasis in Sri Lanka.
The first autochthonous case of visceral leishmaniasis (VL) in Sri Lanka was reported in 2007 [1], more than a decade after the first report of autochthonous cutaneous leishmaniasis (CL) in 1992 [2]. Since 2007 only three endemic patients with confirmed VL was reported from the country (two from the Anuradhapura district), and the current report is on the third patient (from the Vavuniya distri...
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عنوان ژورنال:
دوره 6 شماره
صفحات -
تاریخ انتشار 2016